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Cialis 5 mg: reviews of doctors. Cialis : instructions for use, analogues, prices

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Cialis, along with Viagra, levitra and other similar (not in the sense of the same substance, but in terms of the similarity of pharmacological action), “brand" means to correct erectile dysfunction, is the undoubted conquest of humanity in the glorious cause of combating non-fatal, but with one of the most unpleasant ailments for the male half of it. The pharmacologically active component of Cialis is the substance tadalafil. To understand the mechanism of its action, it is necessary to make a brief excursion into the hemodynamic mysteries of the erection process. Sexual stimulation entails the release from the cavernous bodies of the head of the penis of nitric oxide, which has a mediated vasodilating effect due to activation of the enzyme guanylate cyclase.

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The modern market of medical products is ready to offer its patients a large list of products that will help to cause a qualitative erection for a sufficiently long period. One such means is Cialis. In pharmacies, it can be purchased and one by one (1 tablet), and in packages with a wide variety of (5, 10, 20, 30, 40, 50, 100 pieces).

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pharmachologic effect
A remedy for the treatment of erectile dysfunction is a reversible selective inhibitor of specific PDE5 cGMP. When sexual stimulation causes local release of nitric oxide, inhibition of PDE5 with tadalafil leads to an increase in the level of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and the flow of blood to the tissues of the penis, which causes an erection. Tadalafil is ineffective in the absence of sexual stimulation.

In vitro studies have shown that tadalafil is a selective inhibitor of PDE5. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of internal organs, in skeletal muscles, platelets, kidneys, lungs, and the cerebellum.

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