Actoplus met has active ingredients of metformin hydrochloride; pioglitazone hydrochloride.
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lactic acidosis is not listed as a side effect on the fda label for actos, but it is listed on the labels of actoplus met and actoplus met xr, which contain metformin.
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metformin is known to be substantially excreted by the kidney and because the risk of serious adverse reactions to the drug is greater in patients with impaired renal function, actoplus met should only be used in patients with normal renal function see contraindications , warnings and precautions , and clinical pharmacology .
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generic for actoplus met can interact with other diabetic medications, calcium channel blockers, corticosteroids, thiazide diuretics, thyroid medications, estrogens, oral contraceptives, decongestants, and nicotine replacement medications.
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