Treatment with modified-release dipyridamole plus aspirin followed by aspirin had an icer of 9145 per qaly gained, compared with treatment with aspirin followed by modified-release dipyridamole.
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a dedicated drug interaction study was conducted in 60 healthy volunteers to evaluate the effects of omeprazole 80 mg administered once daily on the pharmacokinetics pk of dipyridamole and the pharmacodynamics pd of acetylsalicylic acid when co-administered with aspirin and extended release dipyridamole capsules twice daily.
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discontinuation due to adverse events in esps2 was 25 for aspirin and extended release dipyridamole capsules, 25 for extended-release dipyridamole, 19 for aspirin, and 21 for placebo refer to table 2 .
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importantly, the analyses found that combined aspirin and dipyridamole reduced the composite vascular outcome as compared with aspirin alone ad a or control ad c .
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